A New Salmonella typhimurium DNA Host Specificity

A new Salmonella typhimurium DNA host specificity.

The genetic properties of a new (hspS) host specificity of Salmonella typhimurium were investigated using bacteriophage L. Phage L is a better substrate for s-specific restriction than phage P22. Mutants deficient in s-restriction only were found at the same frequency as mutants deficient in both restriction and modification. Crosses between S. typhimurium Hfr and S. typhimurium For between Esc...

Chromosomal location of host specificity in Salmonella typhimurium.

Salmonella typhimurium interations with host cells

S. typhimurium is capable of entering into phagocytic and nonphagocytic cells and functiorting as an intracellular pathogen. During invasion of epithelial cells, S. typhimurium causes membrane rffiing and actin rearrangement as it enters. It thetx targets to a specialized vacuole where it replicates. Associated with replication is the ind.uction of a unique host filamentous structure. Isolation...

Caenorhabditis elegans is a model host for Salmonella typhimurium

The idea of using simple, genetically tractable host organisms to study the virulence mechanisms of pathogens dates back at least to the work of Darmon and Depraitère [1]. They proposed using the predatory amoeba Dictyostelium discoideum as a model host, an approach that has proved to be valid in the case of the intracellular pathogen Legionella pneumophila [2]. Research from the Ausubel labora...

Salmonella Serovars and Their Host Specificity

Salmonella is a causative agent for a wide variety of pathological diseases in humans, cattle, poultry and other farm animals and hence Salmonella infections are a major cause of concern to humans, veterinary animals and to food industry. With characterization of over 2500 Salmonella serovars, the pathogen nearly infects all vertebrates but the severity of infection varies from one serovar to a...